Real Madrid are top of the La Liga while Barcelona are one point behind as both teams are struggling for different reasons.
Real Madrid are struggling when English star Jude Bellingham is not on the pitch as the midfielder has 12 goals in 15 matches this season for club and country.
While Brazilian forward Rodrygo has been struggling to find the net as he has the worst return for shots on goal in any of the top 5 leagues.
The Real Madrid trickster scored his first goal in Portugal against Braga on Tuesday and that was his first goal since he scored in the La Liga season opener.
On to their arch rivals Barcelona have been hit by an injury crisis where many of their first team players will miss the top of the table clash.
Spanish midfielder Pedri is one player definitely out of the El Clasico, while there are doubts for Dutchman Frenkie De Jong and Brazilian forward Raphinha.
Robert Lewandowski has been declared fit while he was rested in midweek in the Champions League for their win over Shakhtar Donetsk in Spain.
Barcelona has been a lot more leaky defensively as they have conceded 10 goals in 10 games while they conceded their 10th league goal in their 31st league game last season.